The American journal of tropical medicine and hygiene · 2024
Challenges and Approaches to Establishing Multi-Pathogen Serosurveillance: Findings from the 2023 Serosurveillance Summit.
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Carcelen Andrea C, Kong Alex C, Takahashi Saki, Hegde Sonia, Jaenisch Thomas, Chu May, Rochford Rosemary, Kostandova Natalya, Gurley Emily S, Wesolowski Amy, Azman Andrew S, van der Klis Fiona R M, den Hartog Gerco, Drakeley Christopher, Heaney Christopher D, Winter Amy K, Salje Henrik, Rodriguez-Barraquer Isabel, Leung Daniel T, Njenga Sammy M, Kagucia Eunice Wangeci, Jambo Kondwani C, Wolter Nicole, Charles Richelle C, Saboyá-Díaz Martha-Idalí, Martin Diana L, Moss William J
Аннотация
Multiplex-based serological surveillance is a valuable but underutilized tool to understand gaps in population-level exposure, susceptibility, and immunity to infectious diseases. Assays for which blood samples can be tested for antibodies against several pathogens simultaneously, such as multiplex bead immunoassays, can more efficiently integrate public health surveillance in low- and middle-income countries. On March 7-8, 2023 a group of experts representing research institutions, multilateral organizations, private industry, and country partners met to discuss experiences, identify challenges and solutions, and create a community of practice for integrated, multi-pathogen serosurveillance using multiplex bead assay technologies. Participants were divided into six working groups: 1) supply chain; 2) laboratory assays; 3) seroepidemiology; 4) data analytics; 5) sustainable implementation; and 6) use case scenarios. These working groups discussed experiences, challenges, solutions, and research needs to facilitate integrated, multi-pathogen serosurveillance for public health. Several solutions were proposed to address challenges that cut across working groups.