[A study on the expression of IL-8 and IL-3 in human nasal polyp and polyposis].

OBJECTIVE

To study the expression of IL-8 and IL-3 in human nasal polyp and polyposis.

METHOD: Using immunohistochemical methods detect the expressions of IL-8 and IL-3 in 52 cases of middle turbinate,nasal polyp and nasal polyposis,and calculating the positive area percentages in each group. All datas were analysed with SNK test, Kruskal-Wallis test and Mann-Whitney test.

RESULT: There were very significant differences between either two groups about the expressions of IL-8. There were significant differences between either two groups about the expressions of IL-3.

CONCLUSION

IL-8 is not only one of the causes in nasal polyp, but also plays an important role in the recurrence of nasal polyposis. The expression of IL-8 in polyp is different from that in polyposis, it indicate that polyp and polyposis have different mechanism. IL-3 is important for the accumulation of eosinophil and is a key factor in the mechanism of polyposis.