Journal of the American Academy of Dermatology · 2012
Multivariate analysis of prognostic factors in patients with rapidly progressive alopecia areata.
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Uchiyama Masaki, Egusa Chizu, Hobo Ayako, Irisawa Ryokichi, Yamazaki Masashi, Tsuboi Ryoji
Аннотация
BACKGROUND: Alopecia areata (AA) is a common acquired hair disorder showing variable hair loss. Although various prognostic factors have been reported, no evident factors for determining prognosis and appropriate treatment are known.
OBJECTIVE: To identify prognostic factors in AA patients, especially those with positive results for the hair-pull test on the first visit or with a history of rapidly progressive AA (RPAA) within 6 months prior to the first visit.
METHODS: One thousand thirty (1030) patients diagnosed with AA at Tokyo Medical University Hospital were retrospectively examined for 3 years, and their prognosis was assessed on the basis of various indices using multivariate analysis.
RESULTS: Patients with regenerated vellus hairs showed a significantly higher improvement or cure rate regardless of severity. Early onset and lengthy duration were significantly associated with lower cure, and higher relapse, rates. RPAA patients tended to show a good prognosis regardless of the treatment employed.
LIMITATIONS: The present study is retrospective, and treatment modalities were chosen according to clinical and social circumstances.
CONCLUSION: RPAA patients tend to show a favorable prognosis regardless of treatment modality. Furthermore, the presence of regenerated vellus hairs may indicate a good prognosis.
OBJECTIVE: To identify prognostic factors in AA patients, especially those with positive results for the hair-pull test on the first visit or with a history of rapidly progressive AA (RPAA) within 6 months prior to the first visit.
METHODS: One thousand thirty (1030) patients diagnosed with AA at Tokyo Medical University Hospital were retrospectively examined for 3 years, and their prognosis was assessed on the basis of various indices using multivariate analysis.
RESULTS: Patients with regenerated vellus hairs showed a significantly higher improvement or cure rate regardless of severity. Early onset and lengthy duration were significantly associated with lower cure, and higher relapse, rates. RPAA patients tended to show a good prognosis regardless of the treatment employed.
LIMITATIONS: The present study is retrospective, and treatment modalities were chosen according to clinical and social circumstances.
CONCLUSION: RPAA patients tend to show a favorable prognosis regardless of treatment modality. Furthermore, the presence of regenerated vellus hairs may indicate a good prognosis.