NeuroImage · 2026
Standardized quantification of [18F]Florbetazine amyloid PET with the Centiloid scale.
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Wu Meiqi, Liang Menglin, Mao Chenhui, Dong Liling, Ge Qi, Li Yuying, Wang Jingnan, Ren Chao, Zhang Haiqiong, Huang Zhenghai, Xing Haiqun, Yang Xueqian, Wang Yuan, Wu Runze, Feng Feng, Cui Mengchao, Gao Jing, Huo Li
Аннотация
UNLABELLED: [18F]Florbetazine ([18F]FBZ) is a novel Aβ tracer with imaging characteristics similar to [11C]PiB. This study aimed to establish Centiloid conversion equations for [18F]FBZ and to evaluate its quantification precision relative to [11C]PiB across different image-processing pipelines and effective image resolutions (EIRs).
METHODS: Paired [11C]PiB and [18F]FBZ PET scans were acquired in 53 participants. Centiloid conversion equations for [18F]FBZ standardized uptake value ratio (SUVR), derived from both the standard SPM pipeline and a FreeSurfer pipeline, were calculated following the Level-2 analysis proposed by Klunk et al. The variance ratio of Centiloids derived from [18F]FBZ SUVR to those derived from standard [11C]PiB SUVR in YCs was computed to compare quantification precision. Additionally, the linear relationships between [18F]FBZ and [11C]PiB SUVR were evaluated under different EIRs.
RESULTS: The Centiloid conversion equation for [18F]FBZ SUVR using the standard SPM pipeline was: Centiloid=98.6 × [18F]FBZ SUVRstd-99.8 (variance ratio=0.92). For the FreeSurfer pipeline, the conversion was: Centiloid=110.1 × [18F]FBZ SUVRfs-108.1 (variance ratio=0.55). Robust linear correlations between [11C]PiB and [18F]FBZ SUVR were observed across EIRs with the SPM pipeline, whereas regression parameters varied across EIRs with the FreeSurfer pipeline.
CONCLUSION: [18F]Florbetazine SUVR can be reliably converted to Centiloid units. Compared with [11C]PiB, [18F]FBZ demonstrated equal or improved quantification precision, supporting its broader use in clinical and research Aβ imaging.
METHODS: Paired [11C]PiB and [18F]FBZ PET scans were acquired in 53 participants. Centiloid conversion equations for [18F]FBZ standardized uptake value ratio (SUVR), derived from both the standard SPM pipeline and a FreeSurfer pipeline, were calculated following the Level-2 analysis proposed by Klunk et al. The variance ratio of Centiloids derived from [18F]FBZ SUVR to those derived from standard [11C]PiB SUVR in YCs was computed to compare quantification precision. Additionally, the linear relationships between [18F]FBZ and [11C]PiB SUVR were evaluated under different EIRs.
RESULTS: The Centiloid conversion equation for [18F]FBZ SUVR using the standard SPM pipeline was: Centiloid=98.6 × [18F]FBZ SUVRstd-99.8 (variance ratio=0.92). For the FreeSurfer pipeline, the conversion was: Centiloid=110.1 × [18F]FBZ SUVRfs-108.1 (variance ratio=0.55). Robust linear correlations between [11C]PiB and [18F]FBZ SUVR were observed across EIRs with the SPM pipeline, whereas regression parameters varied across EIRs with the FreeSurfer pipeline.
CONCLUSION: [18F]Florbetazine SUVR can be reliably converted to Centiloid units. Compared with [11C]PiB, [18F]FBZ demonstrated equal or improved quantification precision, supporting its broader use in clinical and research Aβ imaging.