Acta paediatrica (Oslo, Norway : 1992) · 2012
Evidence for oxygen use in preterm infants.
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Bashambu Monuj Triven, Bhola Monika, Walsh Michele
Аннотация
AIM: To review the evidence for optimal oxygen use in preterm infants.
RESULTS: Clinicians have embraced lower saturation targets to minimize retinopathy of prematurity (ROP). Large randomized trials now have shown that while such targets reduce ROP, neonatal mortality is increased significantly.
CONCLUSIONS: Preterm infants should be resuscitated with blended oxygen (30-90%) targeted to avoid hyperoxia. Later, saturation management remains uncertain. Until ongoing trials and follow-up are complete, it is prudent to avoid saturation of 85-89%.
RESULTS: Clinicians have embraced lower saturation targets to minimize retinopathy of prematurity (ROP). Large randomized trials now have shown that while such targets reduce ROP, neonatal mortality is increased significantly.
CONCLUSIONS: Preterm infants should be resuscitated with blended oxygen (30-90%) targeted to avoid hyperoxia. Later, saturation management remains uncertain. Until ongoing trials and follow-up are complete, it is prudent to avoid saturation of 85-89%.