An effective alzheimer disease diagnosis using resting state fmri images and broad learning system.

In this paper, a new multiclass Alzheimer diagnosis system is proposed using Broad Learning (BL) and the combination of Local Coherence (LCOR) and Intrinsic Connectivity Contrast (ICC) parameters. A public resting state fMRI database; including healthy elderly subjects (HC), Alzheimer Disease (AD) and Mild Cognitive Impairment (MCI) patients; was chosen in this study. All rs-fMRI pre-processing and analysis were performed by CONN toolbox. Three contrast cases of AD, MCI and HC were implemented within the group-level analysis, then both LCOR and ICC parameters of the effected brain clusters were combined and collected. For diagnosis system, Broad Learning (BL) classifier is trained to classify three stages of AD, MCI and HC, respectively. Referring to the experimental results and compared with other current studies, the proposed system achieved high average accuracy of 99.6% with low training time of 2 s. Furthermore, a mapping between effected brain regions and their functions is given to interprets the common symptoms for AD and MCI patients.