Vaccine · 1996
Protection of cattle against Fasciola hepatica infection by vaccination with glutathione S-transferase.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Morrison C A, Colin T, Sexton J L, Bowen F, Wicker J, Friedel T, Spithill T W
Аннотация
Glutathione S-transferase (GST) from the liver fluke Fasciola hepatica was assessed as a vaccine immunogen in cattle in a number of immunological adjuvants. Significant reductions in fluke burdens (49-69%) were only observed in cattle vaccinated with GST in Quil Alsqualene Montanide (SM) and PLG microspheres in SM but there was no correlation between anti-GST IgG titres and protection. In separate experiments, animals vaccinated with GST in Quil AlSM were still significantly protected (48%, P < 0.05) 6 months after boosting and no significant differences in protection were seen when the metacercarial challenge was given over 1 month instead of as a single bolus. Inhibition of GST enzyme activity in vitro by cattle antisera did not correlate with reduced fluke burdens.