Медицинская библиотека · Rheumatology (Oxford, England) · 2021

Untargeted lipidomics reveals specific lipid abnormalities in Sjögren's syndrome.

Lu Jiawei, Guo Yunke, Lu Yan, Ji Wei, Lin Lili, Qian Wenjuan, Chen Wenjun, Wang Jue, Lv Xiangyu, Ke Mengying, Kong Deshun, Shen Qiuxiang, Zhu Youjuan, Liu Ping, Su Jinfeng, Wang Lu, Li Yuhua, Gao Pan, Shan Jinjun, Liu Shijia

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVE

The relationship between serum lipid variations in SS and healthy controls was investigated to identify potential predictive lipid biomarkers.

METHODS

Serum samples from 230 SS patients and 240 healthy controls were collected. The samples were analysed by ultrahigh-performance liquid chromatography coupled with Q Exactive™ spectrometry. Potential lipid biomarkers were screened through orthogonal projection to latent structures discriminant analysis and further evaluated by receiver operating characteristic analysis.

RESULTS

A panel of three metabolites [phosphatidylcholine (18:0/22:5), triglyceride (16:0/18:0/18:1) and acylcarnitine (12:0)] was identified as a specific biomarker of SS. The receiver operating characteristic analysis showed that the panel had a sensitivity of 84.3% with a specificity of 74.8% in discriminating patients with SS from healthy controls.

CONCLUSION

Our approach successfully identified serum biomarkers associated with SS patients. The potential lipid biomarkers indicated that SS metabolic disturbance might be associated with oxidized lipids, fatty acid oxidation and energy metabolism.

Для цитирования: Lu Jiawei, Guo Yunke, Lu Yan, Ji Wei, Lin Lili, Qian Wenjuan, Chen Wenjun, Wang Jue, Lv Xiangyu, Ke Mengying, Kong Deshun, Shen Qiuxiang, Zhu Youjuan, Liu Ping, Su Jinfeng, Wang Lu, Li Yuhua, Gao Pan, Shan Jinjun, Liu Shijia. Untargeted lipidomics reveals specific lipid abnormalities in Sjögren's syndrome.. Rheumatology (Oxford, England). 2021. DOI: 10.1093/rheumatology/keaa456.

Предметные рубрики MeSH

Biomarkers Carnitine Case-Control Studies Chromatography, High Pressure Liquid Discriminant Analysis Female Humans Lipidomics Male Mass Spectrometry Phosphatidylcholines Sensitivity and Specificity Sjogren's Syndrome Triglycerides

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