MMP-8 in Peri-Implantitis: A Cross-Sectional Study on Genetic Polymorphisms and Enzymatic Activation.

This graphical abstract illustrates a molecular cascade linking MMP-8 gene polymorphism (-799C/T), upregulated mRNA expression in peri-implant crevicular fluid, and elevated active MMP-8 protein levels. These factors were independently associated with peri-implantitis and may support molecular-based diagnostics.