Bioorganic & medicinal chemistry · 2020
Mangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir - resistant herpes simplex virus 1 infection.
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Rechenchoski Daniele Zendrini, Agostinho Karoline Fontana, Faccin-Galhardi Ligia Carla, Lonni Audrey Alesandra Stinghen Garcia, da Silva João Vinícius Honório, de Andrade Fábio Goulart, Cunha Arcelina Pacheco, Ricardo Nágila Maria Pontes Silva, Nozawa Carlos, Linhares Rosa Elisa Carvalho
Аннотация
Mangiferin is found in many plant species as the mango tree (Mangifera indica) with ethnopharmacological applications and scientific evidence. The emergence of resistant herpes simplex virus (HSV) strains to Acyclovir (ACV) has encouraged the search for new drugs. We investigated the in vitro and in vivo activity of mangiferin obtained from M. indica against ACV-resistant HSV-1 (AR-29) and sensitive (KOS) strains. The in vitro activity was performed under varying treatment protocols. The substance showed a CC50 > 500 μg/mL and IC50 of 2.9 μg/mL and 3.5 μg/mL, respectively, for the AR-29 and KOS strains. The in vivo activity was performed in Balb/c mice treated with 0.7% topical mangiferin formulation. This formulation inhibited most effectively the AR-29 strain, attenuated the lesions, postponed their appearance or enhanced healing, in comparison to control group. We demonstrated the potentiality of mangiferin from M. indica to control HSV replication with emphasis to ACV-resistant infection.