Inflammopharmacology · 2025
COVID-19 in comorbid chronic diseased patients, pregnant and lactating women: pathophysiology, available drug treatment, and the most suitable protocol regimen in each group.
СтатьяСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
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Mohamed Hend M, Elkholy Yara Y, Mokhtar Yara M, Orady Mirna A, Elmetwaly Heba Sh, Abdelwahab Hend Mo, Abdelrady Yasmeen S, Elgohary Mohamed M, Elmahdy Mohamed Kh
Аннотация
BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Comorbidities such as diabetes, chronic cardiovascular diseases, pulmonary diseases, liver diseases, and renal diseases exacerbate the disease, particularly in older patients, pregnant and lactating women.
OBJECTIVE: We performed a systematic review to identify all studies reporting on risks associated with these comorbidities to detect the cause of severity of COVID-19 in these diseases and further selection of the most suitable treatment in each disease.
METHODS: An extensive literature search was performed in the PubMed, Cochrane, and Web of Science databases gathering all available articles. We only selected case-control studies that met inclusion criteria and that focused on high-risk chronic diseased patients, pregnant and lactating women that being infected with COVID-19. Selected studies were grouped into 8 broad categories for review and analysis: (1) pathophysiology of COVID-19, (2) characteristics of COVID-19, (3) common laboratory markers of COVID-19, (4) commonly approved and used treatment of COVID-19, and (5) recommended protocol regimen adjustment in comorbid diseases, pregnant and lactating women.
CONCLUSION: This review focused on pathophysiology of COVID-19 especially in comorbid chronic diseased patients, pregnant and lactating women with the most suitable protocol regimen adjustment in each group.
OBJECTIVE: We performed a systematic review to identify all studies reporting on risks associated with these comorbidities to detect the cause of severity of COVID-19 in these diseases and further selection of the most suitable treatment in each disease.
METHODS: An extensive literature search was performed in the PubMed, Cochrane, and Web of Science databases gathering all available articles. We only selected case-control studies that met inclusion criteria and that focused on high-risk chronic diseased patients, pregnant and lactating women that being infected with COVID-19. Selected studies were grouped into 8 broad categories for review and analysis: (1) pathophysiology of COVID-19, (2) characteristics of COVID-19, (3) common laboratory markers of COVID-19, (4) commonly approved and used treatment of COVID-19, and (5) recommended protocol regimen adjustment in comorbid diseases, pregnant and lactating women.
CONCLUSION: This review focused on pathophysiology of COVID-19 especially in comorbid chronic diseased patients, pregnant and lactating women with the most suitable protocol regimen adjustment in each group.