Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis · 2015
Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for gastric cancer.
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Wang Huiying, Wang Yingnan, Zhao Qun, Guo Zhanjun, Zhang Fengbin, Zhao Yue, Zhang Ruixing
Аннотация
The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in different types of cancers. We investigated the gastric cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 235A/G, 309C/C insert, 324C/G, 16,362T/C and 16,519C/T were significantly associated with an increased risk for gastric cancer, whereas the frequent alleles of nucleotides 523-524AC/del were associated with resistance to gastric cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for gastric cancer risk evaluation.