Journal of pediatric endocrinology & metabolism : JPEM · 2008
Thyroid stimulating immunoglobulin is often negative in children with Graves' disease.
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Rahhal Samar N, Eugster Erica A
Аннотация
BACKGROUND: The diagnosis of Graves' disease (GD) is typically confirmed with a thyroid stimulating immunoglobulin (TSI) titer. While TSI is reported to be positive in >90% of patients with GD, our anecdotal experience suggests that TSI negative GD may be more common in children.
AIM: To investigate the incidence of TSI negative GD in our population and to compare patients with TSI negative vs TSI positive GD.
METHODS: Charts of children with GD seen in our pediatric endocrinology clinic over the past 5 years were reviewed.
RESULTS: Fifty-seven patients with GD were included. TSI was negative in 43% of patients. No significant differences were found in children with TSI negative vs TSI positive GD.
CONCLUSIONS: In patients with GD, the finding of a negative TSI titer usually creates diagnostic uncertainty. However, the fact that nearly half of our patients with GD were TSI negative suggests that this is common in children.
AIM: To investigate the incidence of TSI negative GD in our population and to compare patients with TSI negative vs TSI positive GD.
METHODS: Charts of children with GD seen in our pediatric endocrinology clinic over the past 5 years were reviewed.
RESULTS: Fifty-seven patients with GD were included. TSI was negative in 43% of patients. No significant differences were found in children with TSI negative vs TSI positive GD.
CONCLUSIONS: In patients with GD, the finding of a negative TSI titer usually creates diagnostic uncertainty. However, the fact that nearly half of our patients with GD were TSI negative suggests that this is common in children.