Chinese medical journal · 1997
Anti-acetylcholinesterase antibody in myasthenic syndrome.
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Tang J, Yuan J, Hao H
Аннотация
OBJECTIVE: To examine the relationship between antibodies to acetylcholinesterase and myasthenic syndrome.
METHODS: Serum class specific antibodies to acetylcholinesterase and acetylcholine receptor were prepared with solid phase enzyme-linked immunosorbent assay in 51 patients with myasthenic syndrome, 31 controls with other neurological diseases (diseased controls) and 44 normal controls.
RESULTS: The positive rate of anti-acetylcholinesterase antibody in patients with myasthenic syndrome was 25%, while the results of the other two control groups were negative. Furthermore, the positive rate in patients without myasthenia gravis was 45%, which was much higher than that (13%) in those with myasthenic gravis.
CONCLUSION: Anti-acetylcholinesterase antibody may play a role in the pathogenesis of myasthenic syndrome.
METHODS: Serum class specific antibodies to acetylcholinesterase and acetylcholine receptor were prepared with solid phase enzyme-linked immunosorbent assay in 51 patients with myasthenic syndrome, 31 controls with other neurological diseases (diseased controls) and 44 normal controls.
RESULTS: The positive rate of anti-acetylcholinesterase antibody in patients with myasthenic syndrome was 25%, while the results of the other two control groups were negative. Furthermore, the positive rate in patients without myasthenia gravis was 45%, which was much higher than that (13%) in those with myasthenic gravis.
CONCLUSION: Anti-acetylcholinesterase antibody may play a role in the pathogenesis of myasthenic syndrome.