Medicina clinica · 2008
[Factors related to the length of the corrected QT interval in patients treated with antipsychotics].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Fraguas Herráez David, Laita de Roda Paula, González Balmaseda Guillermo, González Laynez Eugenia, Gamo Bravo Beatriz, Pascual Hernández David, Parellada Redondo Mara, Moreno Pardillo Dolores, Franco Porras Carolina, Llorente Sarabia Cloe, Kushner Steven A, Arango López Celso
Аннотация
BACKGROUND AND OBJECTIVE: The length of the heart-rate corrected QT interval (QTc) has been associated with an increased risk of cardiac dysrhythmia and sudden death. QTc length has been related to age, obesity, poor glycemic control, and use of drugs, such as antipsychotic medications. The objective of this cross-sectional naturalistic study was to assess the factors associated with QTc length in patients treated with antipsychotics.
PATIENTS AND METHOD: Bazett's formula for heart-rate correction was used to compute the corrected QT in 195 psychiatric inpatients treated with antipsychotics -117 males (60.0%), 78 females (40.0%); age (standard deviation): 28.4 (17.3) years (range: 12-84)-.
RESULTS: Older age (p < 0.001) and female gender (p = 0.006) were the only factors significantly related to longer QTc interval. Diagnosis, type of antipsychotic, dosage of antipsychotic, tobacco use, and cardiovascular history were not related to QTc length. Only one male patient with QTc = 455 had a pathological QTc length (females > 470 ms, males > 450 ms).
CONCLUSIONS: Factors related to QTc length in patients treated with antipsychotics are equivalent to those found in previous studies in patients not treated with antipsychotics.
PATIENTS AND METHOD: Bazett's formula for heart-rate correction was used to compute the corrected QT in 195 psychiatric inpatients treated with antipsychotics -117 males (60.0%), 78 females (40.0%); age (standard deviation): 28.4 (17.3) years (range: 12-84)-.
RESULTS: Older age (p < 0.001) and female gender (p = 0.006) were the only factors significantly related to longer QTc interval. Diagnosis, type of antipsychotic, dosage of antipsychotic, tobacco use, and cardiovascular history were not related to QTc length. Only one male patient with QTc = 455 had a pathological QTc length (females > 470 ms, males > 450 ms).
CONCLUSIONS: Factors related to QTc length in patients treated with antipsychotics are equivalent to those found in previous studies in patients not treated with antipsychotics.