Clinical and experimental dermatology · 2016
Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde.
СтатьяМетаанализОбзорНазвание и аннотация: Перевод пока не подготовлен
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Shi M-H, Wu Y, Li L, Cai Y-F, Liu M, Gao X-H, Chen H-D
Аннотация
BACKGROUND: There are conflicting reports on the correlation between vitiligo and the levels of either superoxide dismutase (SOD) or malondialdehyde (MDA).
AIM: To clarify the association between vitiligo and SOD or MDA.
METHODS: Relevant published articles were searched according to our eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% CI.
RESULTS: Patients with either the active or stable vitiligo had higher levels of both SOD (stable: SMD = 1.61, 95% CI 0.66-2.56, P = 0.001; active: SMD = 2.56, 95% CI 1.13-3.99, P < 0.001) and MDA (stable: SMD = 2.70, 95% CI 1.81-3.59, P < 0.001; active: SMD = 3.50, 95% CI 2.29-4.71, P < 0.001), compared with healthy controls.
CONCLUSIONS: This meta-analysis showed a significant association between vitiligo and high levels of both SOD and MDA.
AIM: To clarify the association between vitiligo and SOD or MDA.
METHODS: Relevant published articles were searched according to our eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% CI.
RESULTS: Patients with either the active or stable vitiligo had higher levels of both SOD (stable: SMD = 1.61, 95% CI 0.66-2.56, P = 0.001; active: SMD = 2.56, 95% CI 1.13-3.99, P < 0.001) and MDA (stable: SMD = 2.70, 95% CI 1.81-3.59, P < 0.001; active: SMD = 3.50, 95% CI 2.29-4.71, P < 0.001), compared with healthy controls.
CONCLUSIONS: This meta-analysis showed a significant association between vitiligo and high levels of both SOD and MDA.