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Войти в исследования Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009
A review on the management of epilepsy associated with hypothalamic hamartomas.
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Frazier James L, Goodwin C Rory, Ahn Edward S, Jallo George I
Аннотация
INTRODUCTION: Hypothalamic hamartomas are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Patients may be asymptomatic, but the usual presentation is gelastic seizures, precocious puberty, and/or developmental delay.
CLINICAL PRESENTATION: Without surgical intervention, the gelastic seizures, which are typically present in childhood, may progress to other seizure types, including generalized epilepsy, and are generally refractory to antiepileptic drugs.
SUMMARY: This review will discuss the clinical and electrophysiologic aspects of these lesions, as well as treatment options, including surgery, endoscopy, and radiosurgery.
CLINICAL PRESENTATION: Without surgical intervention, the gelastic seizures, which are typically present in childhood, may progress to other seizure types, including generalized epilepsy, and are generally refractory to antiepileptic drugs.
SUMMARY: This review will discuss the clinical and electrophysiologic aspects of these lesions, as well as treatment options, including surgery, endoscopy, and radiosurgery.