The Journal of pediatrics · 2008
Safety of frequent venous blood sampling in a pediatric research population.
СтатьяМногоцентровое исследованиеПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Broder-Fingert Sarabeth, Crowley William F, Boepple Paul A
Аннотация
OBJECTIVE: To monitor hematological indices in otherwise healthy children with central precocious puberty who underwent frequent venous sampling as part of a longitudinal clinical research study.
STUDY DESIGN: Thirty-four female subjects underwent frequent venous sampling (every 10-20 minutes for 8-16 hours) every 6 months for >or=3 years during and after their treatment with a gonadotropin-releasing hormone analogue. Hemoglobin (Hgb), mean corpuscular volume, and ferritin levels were measured before and after each phlebotomy session.
RESULTS: At baseline, the average Hgb level was 12.5+/-0.7 g/L. At the conclusion of the first sampling session, the Hgb level fell 1.2+/-0.1 g/L, remaining within the reference range for age. At the 3-month follow-up, there was complete recovery of Hgb (12.6+/-0.2 g/L). Longitudinal evaluation every 6 months for as long as 3 years showed no significant differences in Hgb, mean corpuscular volume, or ferritin levels from baseline. No clinically significant adverse effects attributable to phlebotomy were reported.
CONCLUSION: When appropriate safety guidelines were followed, both acute and long-term frequent venous sampling in a pediatric population was safe. Guidelines include monitoring of hematological indices, phlebotomy volume <10 mL/kg/24 hours, and iron replacement.
STUDY DESIGN: Thirty-four female subjects underwent frequent venous sampling (every 10-20 minutes for 8-16 hours) every 6 months for >or=3 years during and after their treatment with a gonadotropin-releasing hormone analogue. Hemoglobin (Hgb), mean corpuscular volume, and ferritin levels were measured before and after each phlebotomy session.
RESULTS: At baseline, the average Hgb level was 12.5+/-0.7 g/L. At the conclusion of the first sampling session, the Hgb level fell 1.2+/-0.1 g/L, remaining within the reference range for age. At the 3-month follow-up, there was complete recovery of Hgb (12.6+/-0.2 g/L). Longitudinal evaluation every 6 months for as long as 3 years showed no significant differences in Hgb, mean corpuscular volume, or ferritin levels from baseline. No clinically significant adverse effects attributable to phlebotomy were reported.
CONCLUSION: When appropriate safety guidelines were followed, both acute and long-term frequent venous sampling in a pediatric population was safe. Guidelines include monitoring of hematological indices, phlebotomy volume <10 mL/kg/24 hours, and iron replacement.