Медицинская библиотека · Scandinavian journal of infectious diseases · 2012

Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children.

Kawashima Hisashi, Morichi Shinichiro, Okumara Akihisa, Nakagawa Satoshi, Morishima Tsuneo, Collaborating Study Group on Influenza-Associated Encephalopathy in Japan

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Аннотация

BACKGROUND

The novel pandemic influenza A (H1N1) 2009 virus (influenza A(H1N1)pdm09) caused an epidemic of critical illness, with some patients developing fatal encephalopathy as well as pneumonia.

METHODS

To investigate the actual efficacy of treatments, we investigated data from questionnaires regarding 207 cases that occurred between September 2009 and February 2010.

RESULTS

The outcomes were recorded in 188 of the 207 cases; 16 of 188 patients died, while 23 had sequelae. Anti-influenza drugs in patients with severe coma (Glasgow coma scale score of ≤ 8) were statistically effective. In 165 out of 199 cases, steroid pulse treatment with methylprednisolone was given at an early stage. Other intensive treatments were mostly administered in serious cases.

CONCLUSIONS

Controlled studies are needed to investigate the efficacy of other treatments except for anti-influenza drugs.

Для цитирования: Kawashima Hisashi, Morichi Shinichiro, Okumara Akihisa, Nakagawa Satoshi, Morishima Tsuneo, Collaborating Study Group on Influenza-Associated Encephalopathy in Japan. Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children.. Scandinavian journal of infectious diseases. 2012. DOI: 10.3109/00365548.2012.700769.

Предметные рубрики MeSH

Anti-Inflammatory Agents Antiviral Agents Child Child, Preschool Encephalitis, Viral Female Humans Influenza A Virus, H1N1 Subtype Influenza, Human Male Surveys and Questionnaires Survival Analysis Treatment Outcome

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