Influence of phospholipids on liver damage. II. Changes in lipid content and synthesis after liver damage with carbontetrachloride and other agents.

Content and synthesis of lipids were studied in rats after carbontetrachloride poisoning and different treatments with phospholipids (EPL), as well as in some other conditions under which an increase in lipids occurs. The increase in neutral lipids during CCl4 poisoning is significantly reduced by pretreatment and--somewhat less--by posttreatment with EPL. Incorporation of acetate into triglycerides, phospholipids and cholesterol increases in CCl4 poisoning and this was not affected by EPL. Moreover, treatment with EPL had but little effect on the lipid accumulation induced by orotic acid feeding and partial hepatectomy. EPL promoted, however, slightly DNA synthesis after partial hepatectomy and protected DNA in thymus after whole body X-irradiation.