Application of the Milan System for Reporting Salivary Gland Cytopathology in pediatric patients: An international, multi-institutional study.
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Maleki Zahra, Saoud Carla, Viswanathan Kartik, Kilic Irem, Tommola Erkka, Griffin Daniel T, Heider Amer, Petrone Gianluigi, Jo Vickie Y, Centeno Barbara A, Saieg Mauro, Mikou Panagiota, Fadda Guido, Ali Syed Z, Kholová Ivana, Wojcik Eva M, Barkan Güliz A, Eisele David W, Bellevicine Claudio, Vigliar Elena, Wiles Austin B, Al-Ibraheemi Alyaa, Allison Derek B, Dixon Glen R, Chandra Ashish, Walsh Jonathan M, Baloch Zubair W, Faquin William C, Krane Jeffrey F, Rossi Esther Diana, Pantanowitz Liron, Troncone Giancarlo, Callegari Fabiano M, Klijanienko Jerzy
Аннотация
METHODS: Pediatric (0- to 21-year-old) salivary gland FNA specimens from 22 international institutions of 7 countries, including the United States, England, Italy, Greece, Finland, Brazil, and France, were retrospectively assigned to an MSRSGC diagnostic category as follows: nondiagnostic, nonneoplastic, atypia of undetermined significance (AUS), benign neoplasm, salivary gland neoplasm of uncertain malignant potential (SUMP), suspicious for malignancy (SM), or malignant. Cytology-histology correlation was performed where available, and the ROM was calculated for each MSRSGC diagnostic category.
RESULTS: The cohort of 477 aspirates was reclassified according to the MSRSGC as follows: nondiagnostic, 10.3%; nonneoplastic, 34.6%; AUS, 5.2%; benign neoplasm, 27.5%; SUMP, 7.5%; SM, 2.5%; and malignant, 12.4%. Histopathologic follow-up was available for 237 cases (49.7%). The ROMs were as follows: nondiagnostic, 5.9%; nonneoplastic, 9.1%; AUS, 35.7%; benign neoplasm, 3.3%; SUMP, 31.8%; SM, 100%; and malignant, 100%. Mucoepidermoid carcinoma was the most common malignancy (18 of 237; 7.6%), and it was followed by acinic cell carcinoma (16 of 237; 6.8%). Pleomorphic adenoma was the most common benign neoplasm (95 of 237; 40.1%).
CONCLUSIONS: The MSRSGC can be reliably applied to pediatric salivary gland FNA. The ROM of each MSRSGC category in pediatric salivary gland FNA is relatively similar to the ROM of each category in adult salivary gland FNA, although the reported rates for the different MSRSGC categories are variable across institutions.