Does sex influence the natural history of idiopathic adult-onset dystonia?
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Velucci Vittorio, Idrissi Sarah, Pellicciari Roberta, Esposito Marcello, Trinchillo Assunta, Belvisi Daniele, Fabbrini Giovanni, Ferrazzano Gina, Terranova Carmen, Girlanda Paolo, Majorana Giovanni, Rizzo Vincenzo, Bono Francesco, Idone Giovanni, Laterza Vincenzo, Avanzino Laura, Di Biasio Francesca, Marchese Roberta, Castagna Anna, Ramella Marina, Lettieri Christian, Rinaldo Sara, Altavista Maria Concetta, Polidori Luigi, Bertolasi Laura, Tozzi Maria Chiara, Erro Roberto, Barone Paolo, Barbero Pierangelo, Ceravolo Roberto, Mascia Marcello Mario, Ercoli Tommaso, Muroni Antonella, Artusi Carlo Alberto, Zibetti Maurizio, Scaglione Cesa Lorella Maria, Bentivoglio Anna Rita, Cotelli Maria Sofia, Magistrelli Luca, Cossu Giovanni, Albanese Alberto, Squintani Giovanna Maddalena, Schirinzi Tommaso, Gigante Angelo Fabio, Maderna Luca, Eleopra Roberto, Pisani Antonio, Cassano Daniela, Romano Marcello, Rizzo Marina, Berardelli Alfredo, Defazio Giovanni, Italian Dystonia Registry Participants
Аннотация
OBJECTIVE: To provide accurate information on the relationship between sex differences, motor phenomenology, dystonia-associated features and the natural history of IAOD.
METHODS: Data of 1701 patients with IAOD from the Italian Dystonia Registry were analysed.
RESULTS: Women predominated over men in blepharospasm, oromandibular, laryngeal and cervical dystonia; the sex ratio was reversed in task-specific upper limb dystonia; and no clear sex difference emerged in non-task-specific upper limb dystonia and lower limb dystonia. This pattern was present at disease onset and the last examination. Women and men did not significantly differ for several dystonia-associated features and tendency to spread. In women and men, the absolute number of individuals who developed dystonia tended to increase from 20 to 60 years and then declined. However, when we stratified by site of dystonia onset, different patterns of female-to-male ratio over time could be observed in the various forms of dystonia.
CONCLUSIONS: Our findings provide novel evidence on sex as a key mediator of IAOD phenotype at disease onset. Age-related sexual dimorphism may result from the varying exposures to specific age-related and sex-related environmental risk factors interacting in a complex manner with biological factors such as hormonal sex factors.