Effect of anti-eosinophil serum on phospholipase B activity in mice infected with Trichinella spiralis.

Anti-eosinophil serum (AES) was administered to mice infected with 400 Trichinella spiralis larvae and its effect on peripheral eosinophilia and intestinal phospholipase B activity was assayed. The AES caused a significant, temporally related, suppression in both peripheral eosinophilia and phospholipase B activity when compared to responses found in infected mice given normal rabbit serum. The findings support the hypothesis that a parasite-induced eosinophilia is the source of elevated phospholipase B activity present in parasitized tissues.