Investigative ophthalmology & visual science · 2004
Simultaneous comparison of relative damage to chromatic pathways in ocular hypertension and glaucoma: correlation with clinical measures.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Castelo-Branco Miguel, Faria Pedro, Forjaz Vasco, Kozak Lajos R, Azevedo Helena
Аннотация
PURPOSE: To use a new methodological approach, based on luminance noise, to assess without bias the relative damage of blue-yellow and red-green pathways in ocular hypertension and glaucoma and to correlate obtained measurements with clinical markers of disease progression.
METHODS: A psychophysical procedure modified from Cambridge color test was used to assess color discrimination in three different groups: patients with primary open-angle glaucoma (n = 51 eyes), patients with ocular hypertension (n = 95 eyes), and control subjects (n = 46 eyes). Viewing conditions were such that the function of the macula was being tested, using a discrimination task under noisy conditions. Confusion vectors, and parameters obtained from discrimination ellipses were correlated with perimetric and clinical data taken from the same groups.
RESULTS: The lengths of the major axis of chromatic discrimination ellipses and all confusion vectors were significantly different between the groups. These measures followed a significant gradient of worsening performance from the control to hypertensive and glaucoma groups, which was steeper for the tritan axis. There was a significant global positive correlation between test parameters and cup-to-disc ratio and a significant negative correlation with the perimetric mean deviation index. Ellipse length in patients with ocular hypertension correlated significantly with the duration of their hypertensive state.
CONCLUSIONS: This psychophysical test can detect visual dysfunction in a significant subset of patients with long-term hypertension with preserved visual fields. Macular function is damaged earlier than previously believed, in both the blue-yellow and red-green pathways.
METHODS: A psychophysical procedure modified from Cambridge color test was used to assess color discrimination in three different groups: patients with primary open-angle glaucoma (n = 51 eyes), patients with ocular hypertension (n = 95 eyes), and control subjects (n = 46 eyes). Viewing conditions were such that the function of the macula was being tested, using a discrimination task under noisy conditions. Confusion vectors, and parameters obtained from discrimination ellipses were correlated with perimetric and clinical data taken from the same groups.
RESULTS: The lengths of the major axis of chromatic discrimination ellipses and all confusion vectors were significantly different between the groups. These measures followed a significant gradient of worsening performance from the control to hypertensive and glaucoma groups, which was steeper for the tritan axis. There was a significant global positive correlation between test parameters and cup-to-disc ratio and a significant negative correlation with the perimetric mean deviation index. Ellipse length in patients with ocular hypertension correlated significantly with the duration of their hypertensive state.
CONCLUSIONS: This psychophysical test can detect visual dysfunction in a significant subset of patients with long-term hypertension with preserved visual fields. Macular function is damaged earlier than previously believed, in both the blue-yellow and red-green pathways.