Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ma Yan, Zhu Dong Shan, Chen Ren Bo, Shi Nan Nan, Liu Si Hong, Fan Yi Pin, Wu Gui Hui, Yang Pu Ye, Bai Jiang Feng, Chen Hong, Chen Li Ying, Feng Qiao, Guo Tuan Mao, Hou Yong, Hu Gui Fen, Hu Xiao Mei, Hu Yun Hong, Huang Jin, Huang Qiu Hua, Huang Shao Zhen, Ji Liang, Jin Hai Hao, Lei Xiao, Li Chun Yan, Li Min Qing, Li Qun Tang, Li Xian Yong, Liu Hong De, Liu Jin Ping, Liu Zhang, Ma Yu Ting, Mao Ya, Mo Liu Fen, Na Hui, Wang Jing Wei, Song Fang Li, Sun Sheng, Wang Dong Ting, Wang Ming Xuan, Wang Xiao Yan, Wang Yin Zhen, Wang Yu Dong, Wu Wei, Wu Lan Ping, Xiao Yan Hua, Xie Hai Jun, Xu Hong Ming, Xu Shou Fang, Xue Rui Xia, Yang Chun, Yang Kai Jun, Yuan Sheng Li, Zhang Gong Qi, Zhang Jin Bo, Zhang Lin Song, Zhao Shu Sen, Zhao Wan Ying, Zheng Kai, Zhou Ying Chun, Zhu Jun Teng, Zhu Tian Qing, Zhang Hua Min, Wang Yan Ping, Wang Yong Yan, 'lung cleansing & detoxifying decoction' emergency project expert group for covid-19
Аннотация
METHODS: A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients' medical records. Multivariable logistic regression models were used to estimate the odds ratio ( OR) and 95% confidence interval (95% CI) of the associations between comorbidities (cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.
RESULTS: Overall, 158 (13.6%) patients were diagnosed with severe illness and 32 (2.7%) had unfavorable outcomes. Hypertension (2.87, 1.30-6.32), type 2 diabetes (T2DM) (3.57, 2.32-5.49), cardiovascular disease (CVD) (3.78, 1.81-7.89), fatty liver disease (7.53, 1.96-28.96), hyperlipidemia (2.15, 1.26-3.67), other lung diseases (6.00, 3.01-11.96), and electrolyte imbalance (10.40, 3.00-26.10) were independently linked to increased odds of being severely ill. T2DM (6.07, 2.89-12.75), CVD (8.47, 6.03-11.89), and electrolyte imbalance (19.44, 11.47-32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission (5.46, 3.25-9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes (6.58, 1.46-29.64) within two weeks.
CONCLUSION: Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.