Effect of nutrition intervention on antioxidant capacity and lipid peroxide in patients with bone marrow transplantation.

OBJECTIVE

To study the effect of exogenous antioxidant vitamins on antioxidant capacity and lipid peroxide status in patients with bone marrow transplantation.

METHODS

Nineteen bone marrow transplantation (BMT) recipients were randomly divided into experimental group (n=10), who received Vit C (300 mg/d) and Vit E (600 mg/d) consecutively 15 d before the initiation of pretreatment of BMT, and the control group (n=9), who received the same treatment only without prior vitamin administration. The levels of ferric-reducing ability of plasma (FRAP), plasma malondialdehyde (MDA), the activity of glutathione peroxidase (GSH-Px) in the blood and the red blood cell superoxide dismutase (RBC-SOD) were measured in both groups before and after the operation.

RESULTS

The levels of FRAP, GSH-Px and RBC-SOD are approximately within the normal range in the experimental group, but below the normal levels in the control group, showing significant differences between the two groups before and after BMT. After BMT, MDA levels in the experimental group soon dropped to normal range, but which in the control group, in contrast,always retained its high levels in the control group in spite of the operation.

CONCLUSION

Exogenous supplementation of antioxidant vitamins before BMT may improve the antioxidant capacity and reduce lipid peroxidation in patients with BMT, effectively alleviating their peroxide stress induced by high-dose chemo/radiotherapy.