Dermatology (Basel, Switzerland) · 1994
Localization of perforin in viral vesicles and erythema multiforme.
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Sayama K, Watanabe Y, Tohyama M, Miki Y
Аннотация
BACKGROUND: Perforin (Pf), a pore-forming protein, is a cytolytic protein of killer cells. Its deposition in lesioned skin has not been studied.
OBJECTIVE: The purpose of this study is to show Pf deposition in the lesioned skin and Pf expression in the dermal infiltrates of various inflammatory skin diseases.
METHODS: Frozen specimens obtained from 29 patients with 5 different diseases were immunohistochemically stained.
RESULTS: Granular deposition of Pf was found in the lesioned skin in 2 out of 5 cases of viral vesicles and in 3 out of 7 cases of erythema multiforme. In the cases with Pf deposition, the percentages of Pf+ cells in the dermis were higher than in those without deposition.
CONCLUSION: Pf released from natural killer cells or cytotoxic T lymphocytes may play a role in tissue damage.
OBJECTIVE: The purpose of this study is to show Pf deposition in the lesioned skin and Pf expression in the dermal infiltrates of various inflammatory skin diseases.
METHODS: Frozen specimens obtained from 29 patients with 5 different diseases were immunohistochemically stained.
RESULTS: Granular deposition of Pf was found in the lesioned skin in 2 out of 5 cases of viral vesicles and in 3 out of 7 cases of erythema multiforme. In the cases with Pf deposition, the percentages of Pf+ cells in the dermis were higher than in those without deposition.
CONCLUSION: Pf released from natural killer cells or cytotoxic T lymphocytes may play a role in tissue damage.
Предметные рубрики MeSH
AdolescentAdultAgedCD4-CD8 RatioChildDermatitis, ContactErythema MultiformeFemaleHerpes ZosterHumansKiller Cells, NaturalLichenoid EruptionsMaleMembrane GlycoproteinsMiddle AgedPemphigoid, BullousPerforinPore Forming Cytotoxic ProteinsSkinSkin Diseases, ViralStaining and LabelingT-Lymphocytes, Cytotoxic