Clinical journal of gastroenterology · 2018
Esophagogastric varices were diagnosed in a non-cirrhotic liver case during long-term follow-up after oxaliplatin-based chemotherapy.
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Shigefuku Ryuta, Watanabe Tsunamasa, Mizukami Takuro, Matsunaga Kotaro, Hattori Nobuhiro, Ehira Takuya, Suzuki Tatsuya, Nakano Hiroyasu, Sato Yoshinori, Matsuo Yasumasa, Nakahara Kazunari, Ikeda Hiroki, Matsumoto Nobuyuki, Tsuda Takashi, Katayama Masafumi, Koizumi Satoshi, Okuse Chiaki, Suzuki Michihiro, Otsubo Takehito, Nakajima Takako Eguchi, Yasuda Hiroshi, Itoh Fumio
Аннотация
Oxaliplatin, a chemotherapeutic agent for colorectal cancer, has been associated with pathological evidence of sinusoidal endothelial injury in the liver. However, esophagogastric varices are a poorly recognized outcome of oxaliplatin-based chemotherapy. We report a 78-year-old man, whose past history of colon cancer was resection and treatment with mFOLFOX6 for 20 weeks, as adjuvant chemotherapy. After 3.5-year follow-up of the oxaliplatin-based chemotherapy, he was diagnosed with esophageal varices without liver dysfunction, indicating that the hepatotoxicity caused by oxaliplatin could be prolonged after its administration. Patients who have received oxaliplatin-based chemotherapy should be followed up carefully over the long term.