Archives of ophthalmology (Chicago, Ill. : 1960) · 2001
Histological effects in the iris after 3 months of latanoprost therapy: the Mainz 1 study.
Клиническое исследованиеСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Pfeiffer N, Grierson I, Goldsmith H, Hochgesand D, Winkgen-Böhres A, Appleton P
Аннотация
OBJECTIVE: To determine whether 3 months of topical latanoprost treatment caused proliferative or degenerative effects on the peripheral iris of patients with glaucoma.
METHODS: Seventeen patients requiring filtering surgery for primary open-angle glaucoma or pseudoexfoliation glaucoma were randomized to receive topical latanoprost for 3 months (n = 8) or alternative medication (n = 9) before surgery. A trabeculectomy and a peripheral iridectomy specimen was obtained from each patient during surgery. The tissue was subjected to histological and immunohistochemical evaluation using 2 cell cycle markers: proliferating cell nuclear antigen and nuclear-associated protein (Ki-67).
RESULTS: No degenerative or pathological changes were seen in the latanoprost-treated irides, including the one specimen in this series in which there was an eye color change. Proliferating cell nuclear antigen and nuclear-associated protein markers were negative for changes in all the test specimens.
CONCLUSION: Short-term treatment with latanoprost does not produce morphological changes or cellular proliferation changes in the iris.
METHODS: Seventeen patients requiring filtering surgery for primary open-angle glaucoma or pseudoexfoliation glaucoma were randomized to receive topical latanoprost for 3 months (n = 8) or alternative medication (n = 9) before surgery. A trabeculectomy and a peripheral iridectomy specimen was obtained from each patient during surgery. The tissue was subjected to histological and immunohistochemical evaluation using 2 cell cycle markers: proliferating cell nuclear antigen and nuclear-associated protein (Ki-67).
RESULTS: No degenerative or pathological changes were seen in the latanoprost-treated irides, including the one specimen in this series in which there was an eye color change. Proliferating cell nuclear antigen and nuclear-associated protein markers were negative for changes in all the test specimens.
CONCLUSION: Short-term treatment with latanoprost does not produce morphological changes or cellular proliferation changes in the iris.
Предметные рубрики MeSH
Administration, TopicalAdultAgedAged, 80 and overAntihypertensive AgentsBiomarkersExfoliation SyndromeFemaleGlaucoma, Open-AngleHumansImmunoenzyme TechniquesIntraocular PressureIrisKi-67 AntigenLatanoprostMaleMiddle AgedOphthalmic SolutionsProliferating Cell Nuclear AntigenProstaglandins F, SyntheticSingle-Blind MethodTrabeculectomy