Childhood trauma moderates schizotypy-related brain morphology: analyses of 1182 healthy individuals from the ENIGMA schizotypy working group.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Quidé Yann, Watkeys Oliver J, Tonini Emiliana, Grotegerd Dominik, Dannlowski Udo, Nenadić Igor, Kircher Tilo, Krug Axel, Hahn Tim, Meinert Susanne, Goltermann Janik, Gruber Marius, Stein Frederike, Brosch Katharina, Wroblewski Adrian, Thomas-Odenthal Florian, Usemann Paula, Straube Benjamin, Alexander Nina, Leehr Elisabeth J, Bauer Jochen, Winter Nils R, Fisch Lukas, Dohm Katharina, Rössler Wulf, Smigielski Lukasz, DeRosse Pamela, Moyett Ashley, Houenou Josselin, Leboyer Marion, Gilleen James, Thomopoulos Sophia I, Thompson Paul M, Aleman André, Modinos Gemma, Green Melissa J
Аннотация
METHODS: We addressed this question using data from a total of 1182 healthy adults (age range: 18-65 years old, 647 females/535 males), pooled from nine sites worldwide, contributing to the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Schizotypy working group. All participants completed both the Schizotypal Personality Questionnaire Brief version (SPQ-B), and the Childhood Trauma Questionnaire (CTQ), and underwent a 3D T1-weighted brain MRI scan from which regional indices of subcortical gray matter volume and cortical thickness were determined.
RESULTS: A series of multiple linear regressions revealed that differences in cortical thickness in four regions-of-interest were significantly associated with interactions between schizotypy and trauma; subsequent moderation analyses indicated that increasing levels of schizotypy were associated with thicker left caudal anterior cingulate gyrus, right middle temporal gyrus and insula, and thinner left caudal middle frontal gyrus, in people exposed to higher (but not low or average) levels of childhood trauma. This was found in the context of morphological changes directly associated with increasing levels of schizotypy or increasing levels of childhood trauma exposure.
CONCLUSIONS: These results suggest that alterations in brain regions critical for higher cognitive and integrative processes that are associated with schizotypy may be enhanced in individuals exposed to high levels of trauma.