Zhonghua nei ke za zhi · 2009
[A study on the expression of anti-mitochondrial antibody in the brain of patients with MELAS syndrome].
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Qi Xiao-Kun, Yao Sheng, Wang Hai-Yan, Piao Yue-Shan, Lu De-Hong, Yuan Yun
Аннотация
OBJECTIVE: To investigate the pathological changes and pathogenesis of the MELAS syndrome (mitochondrial encephalopathy lactic acidosis stroke-like episodes) by using the method of immunohistochemical staining in the brain biopsy specimens with anti-mitochondrial antibody (AMA).
METHODS: We performed immunohistochemical staining in 3 confirmed MELAS patients' paraffin-imbued brain biopsy specimens.
RESULTS: Small vessel proliferation and the uneven thickness of the wall were found in the 3 MELAS patients. A lot of brown deposits was shown in the wall of small vessels and also noted in neurons.
CONCLUSIONS: The main pathological change in the MELAS brain biopsy immunohistochemical staining with AMA was the small vessel proliferation, indicating that abnormal mitochondria accumulated in the vascular smooth muscle, endothelial cell and neurons of the lesion sites. This finding was consistent with the electron microscopic discovery and valuable for the diagnosis of MELAS.
METHODS: We performed immunohistochemical staining in 3 confirmed MELAS patients' paraffin-imbued brain biopsy specimens.
RESULTS: Small vessel proliferation and the uneven thickness of the wall were found in the 3 MELAS patients. A lot of brown deposits was shown in the wall of small vessels and also noted in neurons.
CONCLUSIONS: The main pathological change in the MELAS brain biopsy immunohistochemical staining with AMA was the small vessel proliferation, indicating that abnormal mitochondria accumulated in the vascular smooth muscle, endothelial cell and neurons of the lesion sites. This finding was consistent with the electron microscopic discovery and valuable for the diagnosis of MELAS.