The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2014
Latent tuberculous infection prevalence among paediatric contacts of drug-resistant and drug-susceptible cases.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Laniado-Laborín R, Cazares-Adame R, Volker-Soberanes M-L, del Portillo-Mustieles C, Villa-Rosas C, Oceguera-Palao L, Magallanes-Mijares J
Аннотация
SETTING: Tuberculosis (TB) clinic in Tijuana, México.
BACKGROUND: Tuberculin conversion rates in contacts of drug-resistant cases have been reported to be lower than among contacts of drug-susceptible cases.
OBJECTIVE: To determine if the prevalence of latent tuberculous infection (LTBI) among paediatric contacts of drug-resistant cases is lower than that of contacts of drug-susceptible cases.
DESIGN: In a cross-sectional study, LTBI among paediatric contacts of culture-proven TB cases was evaluated using the tuberculin skin test and interferon-gamma release assay. Rates among contacts of drug-susceptible and drug-resistant cases were compared.
RESULTS: The TST was positive in 83.1% of the drug-susceptible group vs. 76.0% for the drug-resistant group (P = 0.25). Using the QuantiFERON Gold In-Tube (QFT-GIT) assay, drug-resistant cases had a higher rate of positivity than the drug-susceptible group, although this difference did not reach statistical significance (42.3% positivity among drug-susceptible cases vs. 57.7% among drug-resistant cases; P = 0.48).
CONCLUSIONS: The proportion of LTBI is similar among paediatric contacts, regardless of whether the index case is drug-resistant or -susceptible.
BACKGROUND: Tuberculin conversion rates in contacts of drug-resistant cases have been reported to be lower than among contacts of drug-susceptible cases.
OBJECTIVE: To determine if the prevalence of latent tuberculous infection (LTBI) among paediatric contacts of drug-resistant cases is lower than that of contacts of drug-susceptible cases.
DESIGN: In a cross-sectional study, LTBI among paediatric contacts of culture-proven TB cases was evaluated using the tuberculin skin test and interferon-gamma release assay. Rates among contacts of drug-susceptible and drug-resistant cases were compared.
RESULTS: The TST was positive in 83.1% of the drug-susceptible group vs. 76.0% for the drug-resistant group (P = 0.25). Using the QuantiFERON Gold In-Tube (QFT-GIT) assay, drug-resistant cases had a higher rate of positivity than the drug-susceptible group, although this difference did not reach statistical significance (42.3% positivity among drug-susceptible cases vs. 57.7% among drug-resistant cases; P = 0.48).
CONCLUSIONS: The proportion of LTBI is similar among paediatric contacts, regardless of whether the index case is drug-resistant or -susceptible.