Medical mycology · 2015
The bone marrow represents an enrichment site of specific T lymphocytes against filamentous fungi.
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Vallerini Daniela, Riva Giovanni, Barozzi Patrizia, Forghieri Fabio, Lagreca Ivana, Quadrelli Chiara, Morselli Monica, Bresciani Paola, Cuoghi Angela, Coluccio Valeria, Maccaferri Monica, Paolini Ambra, Colaci Elisabetta, Marasca Roberto, Narni Franco, Latgè Jean-Paul, Romani Luigina, Comoli Patrizia, Campioli Daniele, Trenti Tommaso, Luppi Mario, Potenza Leonardo
Аннотация
Bone marrow has already been described as an enrichment site for several antigen-specific T lymphocytes, but the presence of mould-specific T cells has never been investigated in the bone marrow. We have previously demonstrated that mould-specific T cells emerge in the peripheral blood of patients with invasive fungal infections (IFI) but tend to become undetectable after disease resolution. In seven patients with a history of IFI, we investigated the presence of mould-specific T cells secreting different cytokines in bone marrow and peripheral blood paired samples. The results showed that the frequencies of mould-specific T cells secreting the protective cytokine IFNγ are significantly higher in bone marrow (BM) and are mainly represented by CD8+ T lymphocytes with effector phenotype. A putative disappearance of such protective BM responses after myeloablative therapy could contribute to the increased risk of IFI in hematologic patients.