Internal medicine (Tokyo, Japan) · 2019
Role of NS5A-L31/Y93 Double Wild-type in Failure of Glecaprevir/Pibrentasvir Double Therapy in Two Patients with a History of Direct-acting Antiviral Agent Failure: An Ultra-deep Sequencing Analysis.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Sano Tomoya, Akuta Norio, Suzuki Fumitaka, Kasuya Kayoko, Fujiyama Shunichiro, Kawamura Yusuke, Sezaki Hitomi, Hosaka Tetsuya, Saitoh Satoshi, Kobayashi Masahiro, Suzuki Yoshiyuki, Kobayashi Mariko, Arase Yasuji, Ikeda Kenji, Kumada Hiromitsu
Аннотация
We experienced two cases of hepatitis C virus (HCV) eradication failure in patients with a history of non-responsiveness to previous treatments with direct-acting antiviral agents (DAAs) who were subsequently treated with the combination of glecaprevir and pibrentasvir (GLE/PIB). Direct sequencing at commencement of GLE/PIB therapy showed non-structural protein (NS) 5A-P32 deletion in the first patient and NS5A-R30E/Q54H/A92K in the second patient (both genotype 1b). The common point was that L31/Y93 was double wild-type, and the IL28B polymorphism was non-TT type. Even when L31/Y93 is double wild-type, other NS5A mutations may affect the DAA re-treatment outcome. We analyzed the transition of amino acid mutations at NS5A by ultra-deep sequencing.