Nature communications · 2023
Detecting temporal and spatial malaria patterns from first antenatal care visits.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Pujol Arnau, Brokhattingen Nanna, Matambisso Glória, Mbeve Henriques, Cisteró Pau, Escoda Anna, Maculuve Sónia, Cuna Boaventura, Melembe Cardoso, Ndimande Nelo, Munguambe Humberto, Montaña Júlia, Nhamússua Lídia, Simone Wilson, Tetteh Kevin K A, Drakeley Chris, Gamain Benoit, Chitnis Chetan E, Chauhan Virander, Quintó Llorenç, Chidimatembue Arlindo, Martí-Soler Helena, Galatas Beatriz, Guinovart Caterina, Saúte Francisco, Aide Pedro, Macete Eusébio, Mayor Alfredo
Аннотация
Pregnant women attending first antenatal care (ANC) visits represent a promising malaria surveillance target in Sub-Saharan Africa. We assessed the spatio-temporal relationship between malaria trends at ANC (n = 6471) and in children in the community (n = 3933) and at health facilities (n = 15,467) in southern Mozambique (2016-2019). ANC P. falciparum rates detected by quantitative polymerase chain reaction mirrored rates in children, regardless of gravidity and HIV status (Pearson correlation coefficient [PCC] > 0.8, χ²<1.1), with a 2-3 months lag. Only at rapid diagnostic test detection limits at moderate-to-high transmission, did multigravidae show lower rates than children (PCC = 0.61, 95%CI[-0.12-0.94]). Seroprevalence against the pregnancy-specific antigen VAR2CSA reflected declining malaria trends (PCC = 0.74, 95%CI[0.24-0.77]). 60% (9/15) of hotspots detected from health facility data (n = 6662) using a novel hotspot detector, EpiFRIenDs, were also identified with ANC data (n = 3616). Taken together, we show that ANC-based malaria surveillance offers contemporary information on temporal trends and geographic distribution of malaria burden in the community.