Immunology letters · 2023
Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model.
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de Jong G M, Yap X Z, Walk J, Dik W A, McCall M B B, van Genderen P J J, van Hellemond J J, Verbon A, Sauerwein R W
Аннотация
BACKGROUND: Here we assessed a possible relationship between baseline TGF-β concentrations and acquisition of sterile immunity after Plasmodium falciparum sporozoite immunization.
METHODS: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites.
RESULTS: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028).
CONCLUSION: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.
METHODS: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites.
RESULTS: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028).
CONCLUSION: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.