Nuclear medicine review. Central & Eastern Europe · 2012
Localisation of sentinel lymph nodes in patients with melanomas by planar lymphoscintigraphic and hybrid SPECT/CT imaging.
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Kraft Otakar, Havel Martin
Аннотация
BACKGROUND: The aim of the study was to assess the role of planar lymphoscintigraphy and fusion imaging of SPECT/CT in sentinel lymph node (SLN) identification in patients with melanomas.
MATERIAL AND METHODS: Planar and hybrid SPECT/low-dose CT lymphoscintigraphy were performed in 113 consecutive patients with melanomas (59 men, 54 women, mean age 57.6 with range 11-87 years, BMI 29.4 ± 12.5). The radiopharmaceutical was injected around the tumour (Group A, 59 patients), or around the scar (Group B, 54 patients). Localisation of melanomas: head and neck 4, trunk 55, upper extremities 28, lower extremities 26. Planar and SPECT/CT images were interpreted separately by two nuclear medicine physicians. Abilities of these two techniques to image SLN were compared.
RESULTS: SLNs were detected on lymphoscintigraphy comprising planar and SPECT-CT images in 108 (95.6%) study patients; there was failure to detect SLNs in the remaining 5 (4.4%) patients. Planar images identified 253 SLNs in 100 (88.5%) pts, with a mean of 2.2 ± 1.7 (range 0-9 nodes) per patient. In the remaining 13 (11.5%) patients no SLNs were detected on planar images. On SPECT-CT images, 334 hot nodes were detected in 107 (94.7%) patients with a mean of 3.0 ± 2.1 (range 0-9) nodes per patient. In the remaining 6 (5.3%) patients, SPECT-CT was negative. SPECT/CT visualised lymphatic drainage in 8 (7.1%) patients with non-visualisation on planar imaging.
CONCLUSIONS: In some patients with melanomas SPECT/CT improves detection of sentinel lymph nodes. It can image nodes not visible on planar scintigrams, exclude false positive uptake and exactly localize SLNs.
MATERIAL AND METHODS: Planar and hybrid SPECT/low-dose CT lymphoscintigraphy were performed in 113 consecutive patients with melanomas (59 men, 54 women, mean age 57.6 with range 11-87 years, BMI 29.4 ± 12.5). The radiopharmaceutical was injected around the tumour (Group A, 59 patients), or around the scar (Group B, 54 patients). Localisation of melanomas: head and neck 4, trunk 55, upper extremities 28, lower extremities 26. Planar and SPECT/CT images were interpreted separately by two nuclear medicine physicians. Abilities of these two techniques to image SLN were compared.
RESULTS: SLNs were detected on lymphoscintigraphy comprising planar and SPECT-CT images in 108 (95.6%) study patients; there was failure to detect SLNs in the remaining 5 (4.4%) patients. Planar images identified 253 SLNs in 100 (88.5%) pts, with a mean of 2.2 ± 1.7 (range 0-9 nodes) per patient. In the remaining 13 (11.5%) patients no SLNs were detected on planar images. On SPECT-CT images, 334 hot nodes were detected in 107 (94.7%) patients with a mean of 3.0 ± 2.1 (range 0-9) nodes per patient. In the remaining 6 (5.3%) patients, SPECT-CT was negative. SPECT/CT visualised lymphatic drainage in 8 (7.1%) patients with non-visualisation on planar imaging.
CONCLUSIONS: In some patients with melanomas SPECT/CT improves detection of sentinel lymph nodes. It can image nodes not visible on planar scintigrams, exclude false positive uptake and exactly localize SLNs.