Effects of brimonidine 0.2% on blue-yellow perimetry of glaucomatous patients.

A cross-over double-blind study was performed to evaluate the effect of acute administration of brimonidine on the blue-yellow perimetry. Thirty patients with primary open-angle glaucoma were admitted. After brimonidine administration, IOP and pupil diameter showed a significant reduction (p < 0.01) without modification in systolic and diastolic blood pressure. Blue-on-yellow perimetry showed a significant reduction in CPSD from 3.81 +/- 1.60 to 2.71 +/- 1.92 (p < 0.05). This result suggests that brimonidine improves ocular perfusion via a reduction of IOP.