Journal of affective disorders · 1999
Guanfacine and secondary mania in children.
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Horrigan J P, Barnhill L J
Аннотация
INTRODUCTION: Guanfacine hydrochloride is an alpha-2 adrenergic agonist, which has gained recent attention in the field of child and adolescent psychiatry. This medication has been described as effective in the management of attention-deficit hyperactivity and tic disorders, with minimal side effects.
METHODS: Presented here are five cases of behavioral activation in children treated with guanfacine.
RESULTS: In each instance the clinical presentation resembled an acute hypomanic or manic episode. The dose of guanfacine was 0.5 mg/day. Later investigation revealed that all of the youngsters had clear risk factors (clinical and/or familial) for bipolar disorder.
CONCLUSIONS: It appears as though guanfacine may be capable of precipitating secondary mania in vulnerable children.
METHODS: Presented here are five cases of behavioral activation in children treated with guanfacine.
RESULTS: In each instance the clinical presentation resembled an acute hypomanic or manic episode. The dose of guanfacine was 0.5 mg/day. Later investigation revealed that all of the youngsters had clear risk factors (clinical and/or familial) for bipolar disorder.
CONCLUSIONS: It appears as though guanfacine may be capable of precipitating secondary mania in vulnerable children.