Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2006
Anti-inflammatory agents in the management of alimentary mucositis.
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Lalla Rajesh V, Schubert Mark M, Bensadoun Rene-Jean, Keefe Dorothy
Аннотация
BACKGROUND: Alimentary mucositis is a significant complication of cancer therapy, with important clinical and economic implications.
MATERIALS AND METHODS: In June 2005, the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology conducted an evidence-based review of the literature on alimentary mucositis. The goal of this literature review was to update previously published guidelines for the management of mucositis.
RESULTS: This article reports the findings of the subgroup charged with reviewing the literature related to anti-inflammatory interventions. Considerable preclinical and clinical evidence suggests that the use of anti-inflammatory agents may be a promising approach to reduce the severity of mucositis. However, there was not enough evidence to support any new guidelines advocating the use of any specific anti-inflammatory intervention.
CONCLUSION: Thus, there is a need for well-designed clinical trials evaluating the use of anti-inflammatory agents in the management of mucositis.
MATERIALS AND METHODS: In June 2005, the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology conducted an evidence-based review of the literature on alimentary mucositis. The goal of this literature review was to update previously published guidelines for the management of mucositis.
RESULTS: This article reports the findings of the subgroup charged with reviewing the literature related to anti-inflammatory interventions. Considerable preclinical and clinical evidence suggests that the use of anti-inflammatory agents may be a promising approach to reduce the severity of mucositis. However, there was not enough evidence to support any new guidelines advocating the use of any specific anti-inflammatory intervention.
CONCLUSION: Thus, there is a need for well-designed clinical trials evaluating the use of anti-inflammatory agents in the management of mucositis.
Предметные рубрики MeSH
AllopurinolAnimalsAnti-Inflammatory AgentsAnti-Ulcer AgentsAntineoplastic AgentsBenzydamineClinical Trials as TopicDrug EvaluationEvidence-Based MedicineFlurbiprofenGastrointestinal DiseasesHealth Services Needs and DemandHumansMetalloproteinsMisoprostolMucositisNeoplasmsPractice Guidelines as TopicRadiation-Protective AgentsRadiotherapyResearch DesignSeverity of Illness IndexStomatitisTriazines