The American journal of psychiatry · 2006
Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Babulas Vicki, Factor-Litvak Pam, Goetz Raymond, Schaefer Catherine A, Brown Alan S
Аннотация
OBJECTIVE: In this birth cohort study, the authors examined the relation between prenatal exposure to maternal genital/reproductive (G/R) infections and schizophrenia in offspring.
METHOD: The birth cohort consisted of 7,794 offspring of pregnancies with prospectively acquired data on maternal G/R infections from obstetric records. The authors diagnosed 71 cases of schizophrenia and other schizophrenia spectrum disorders in this cohort. The relationship between maternal G/R infections and schizophrenia risk was modeled.
RESULTS: Exposure to G/R infections during the periconceptional period was associated with a significantly increased risk of schizophrenia and other schizophrenia spectrum disorders, with adjustment for maternal race, education, age, and mental illness.
CONCLUSIONS: Maternal G/R infection during periconception appears to increase the risk of schizophrenia in offspring.
METHOD: The birth cohort consisted of 7,794 offspring of pregnancies with prospectively acquired data on maternal G/R infections from obstetric records. The authors diagnosed 71 cases of schizophrenia and other schizophrenia spectrum disorders in this cohort. The relationship between maternal G/R infections and schizophrenia risk was modeled.
RESULTS: Exposure to G/R infections during the periconceptional period was associated with a significantly increased risk of schizophrenia and other schizophrenia spectrum disorders, with adjustment for maternal race, education, age, and mental illness.
CONCLUSIONS: Maternal G/R infection during periconception appears to increase the risk of schizophrenia in offspring.