Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology.
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Bellaver Bruna, Puig-Pijoan Albert, Ferrari-Souza João Pedro, Leffa Douglas T, Lussier Firoza Z, Ferreira Pamela C L, Tissot Cécile, Povala Guilherme, Therriault Joseph, Benedet Andréa L, Ashton Nicholas J, Servaes Stijn, Chamoun Mira, Stevenson Jenna, Rahmouni Nesrine, Vermeiren Marie, Macedo Arthur C, Fernández-Lebrero Aida, García-Escobar Greta, Navalpotro-Gómez Irene, Lopez Oscar, Tudorascu Dana L, Cohen Ann, Villemagne Victor L, Klunk William E, Gauthier Serge, Zimmer Eduardo R, Karikari Thomas K, Blennow Kaj, Zetterberg Henrik, Suárez-Calvet Marc, Rosa-Neto Pedro, Pascoal Tharick A
Аннотация
METHODS: We assessed 224 participants in research (TRIAD, n = 96) and clinical (BIODEGMAR, n = 128) cohorts with plasma and CSF/positron emission tomography Aβ, p-tau, and albumin measures.
RESULTS: Plasma Aβ42/40 better identified CSF Aβ42/40 and Aβ-PET positivity in individuals with high BBB permeability. An interaction between plasma Aβ42/40 and BBB permeability on CSF Aβ42/40 was observed. Voxel-wise models estimated that the association of positron emission tomography (PET), with plasma Aβ was most affected by BBB permeability in AD-related brain regions. BBB permeability did not significantly impact the relationship between brain and plasma p-tau levels.
DISCUSSION: These findings suggest that BBB integrity may influence the performance of plasma Aβ, but not p-tau, biomarkers in research and clinical settings.
HIGHLIGHTS: BBB permeability affects the association between brain and plasma Aβ levels. BBB integrity does not affect the association between brain and plasma p-tau levels. Plasma Aβ was most affected by BBB permeability in AD-related brain regions. BBB permeability increases with age but not according to cognitive status.