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[Impact of COVID-19 pandemic on the etiology and severity of respiratory viral infections in children].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Sominina A А, Danilenko D M, Komissarov A B, Fadeev A V, Komissarova K S, Pisareva M M, Musayeva T D, Eder V A, Levanyuk T P, Stolyarov K A, Krivitskaya V Z, Petrova E R, Afanasyeva O I, Timonina V S, Obraztsova E V, Golovacheva E G, Dondurey E A, Lelenkova E V, Kurskaya O G, Shestopalov A M, Lioznov D A
Аннотация
OBJECTIVE: To analyze the age-related characteristics of the contribution of influenza viruses, RSV, SARS-CoV-2, other pathogens to the development of severe acute respiratory infections (SARI) in children with an assessment of the disease severity depending on its etiology and epidemic period.
MATERIALS AND METHODS: SARI monitoring was carried out over six consecutive epidemic seasons, starting from 2018-2019 in 9 infectious hospitals of three cities of Russia with an assessment of the disease severity depending on its etiology.
RESULTS: Among all hospitalized children, the proportion of children hospitalized with laboratory-confirmed influenza from 2018 to 2020 ranged from 25.7% to 44.7%, and for RSV infection from 25.7% to 26.8%. However, during the peak of the pandemic, these rates dropped significantly to 0.3% and 1.7%, respectively. In the subsequent three seasons (2021-2024), laboratory-confirmed influenza among hospitalized children was registered in 4.5-20.2% of cases, while RSV infection was identified in 13.4-24.1% of cases, accompanied by a shift in viral subgroups. RSV infections were most severe during the 2022-2023 season, presenting in some cases with hyperthermia, hypoxia, dyspnea, and altered consciousness. Among hospitalized children, the proportion with COVID-19 was relatively low in 2020-2021 (0.8-2.4%) but increased significantly to 10.6%-13.6% following the emergence of the Omicron variant in 2022, before decreasing again in subsequent years. The main genetic lineages of SARS-CoV-2 circulating in the Russian Federation are presented.
CONCLUSION: Influenza and RSV viruses were predominant among viral pathogens identified in hospitalized children aged ≤ 2 years. COVID-19 cases among children were relatively rare and generally less severe compared to RSV and rhinovirus infections.
MATERIALS AND METHODS: SARI monitoring was carried out over six consecutive epidemic seasons, starting from 2018-2019 in 9 infectious hospitals of three cities of Russia with an assessment of the disease severity depending on its etiology.
RESULTS: Among all hospitalized children, the proportion of children hospitalized with laboratory-confirmed influenza from 2018 to 2020 ranged from 25.7% to 44.7%, and for RSV infection from 25.7% to 26.8%. However, during the peak of the pandemic, these rates dropped significantly to 0.3% and 1.7%, respectively. In the subsequent three seasons (2021-2024), laboratory-confirmed influenza among hospitalized children was registered in 4.5-20.2% of cases, while RSV infection was identified in 13.4-24.1% of cases, accompanied by a shift in viral subgroups. RSV infections were most severe during the 2022-2023 season, presenting in some cases with hyperthermia, hypoxia, dyspnea, and altered consciousness. Among hospitalized children, the proportion with COVID-19 was relatively low in 2020-2021 (0.8-2.4%) but increased significantly to 10.6%-13.6% following the emergence of the Omicron variant in 2022, before decreasing again in subsequent years. The main genetic lineages of SARS-CoV-2 circulating in the Russian Federation are presented.
CONCLUSION: Influenza and RSV viruses were predominant among viral pathogens identified in hospitalized children aged ≤ 2 years. COVID-19 cases among children were relatively rare and generally less severe compared to RSV and rhinovirus infections.