Epilepsy research · 2025
Theta functional connectivity alterations related to executive control in refractory temporal lobe epilepsy.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhan Changqing, Wang Qiao, Wang Wenyu, Lu Xueping, Fei Shizao, Chen Zongsheng, Chen Yingnian
Аннотация
AIMS: Using the attention network test (ANT) with simultaneous electroencephalography (EEG) recordings, this study investigated the neural mechanisms underlying executive control (EC) dysfunction in patients with temporal lobe refractory epilepsy.
METHODS: Participants comprised three demographically matched groups (n = 20 each): refractory temporal lobe epilepsy (RE), drug-sensitive temporal lobe epilepsy (DSE), and healthy controls (Ctrl). Participants were instructed to perform the ANT while scalp EEG signals were simultaneously recorded. Theta-band functional connectivity was computed from EEG data acquired during ANT task execution.
RESULTS: The RE group exhibited significant impairment in EC performance. Theta-band functional connectivity strength in the whole-brain and frontal regions of the EC network was significantly reduced in both patient groups (RE/DSE) versus healthy controls. Notably, the RE group demonstrated reduced whole-brain and frontal theta connectivity within the EC network relative to the DSE group. Furthermore, frontal theta connectivity strength positively correlated with EC_effect in both Ctrl and DSE groups (r = -0.658, p = 0.002; r = -0.540, p = 0.014). In contrast, no significant association was observed between EC network theta connectivity and behavioral performance in the RE group (p > 0.05).
CONCLUSION: Patients with refractory epilepsy exhibited impaired EC behavioral performance, concomitant with reduced theta-band functional connectivity strength in frontal regions. This diminished frontal theta connectivity may underlie EC dysfunction in this patient population.
METHODS: Participants comprised three demographically matched groups (n = 20 each): refractory temporal lobe epilepsy (RE), drug-sensitive temporal lobe epilepsy (DSE), and healthy controls (Ctrl). Participants were instructed to perform the ANT while scalp EEG signals were simultaneously recorded. Theta-band functional connectivity was computed from EEG data acquired during ANT task execution.
RESULTS: The RE group exhibited significant impairment in EC performance. Theta-band functional connectivity strength in the whole-brain and frontal regions of the EC network was significantly reduced in both patient groups (RE/DSE) versus healthy controls. Notably, the RE group demonstrated reduced whole-brain and frontal theta connectivity within the EC network relative to the DSE group. Furthermore, frontal theta connectivity strength positively correlated with EC_effect in both Ctrl and DSE groups (r = -0.658, p = 0.002; r = -0.540, p = 0.014). In contrast, no significant association was observed between EC network theta connectivity and behavioral performance in the RE group (p > 0.05).
CONCLUSION: Patients with refractory epilepsy exhibited impaired EC behavioral performance, concomitant with reduced theta-band functional connectivity strength in frontal regions. This diminished frontal theta connectivity may underlie EC dysfunction in this patient population.