Significance of measurement of antihyaluronidase activity in rheumatic fever.

In recent years, rheumatic fever seems to have decreased but rheumatic heart disease with latent onset appears to persist in similar frequency. Measurement of AH along with ASO is required in rheumatic heart disease with latent onset, for more definite diagnosis, therapy and suggestion for the mode of living. For the diagnosis of rheumatic fever in acute stage, serological reactions for hemolytic streptococcus other than ASO should be done along with ASO. In our cases, ASO titer was high in 84.5% of cases, but either ASO or AH titer was elevated indicating positive reaction for hemolytic streptococcus in 100% of cases.