Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2023
3-acetylpyridine induced behavioral dysfunction and neuronal loss in the striatum and hippocampus of adult male rats.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Ghorbani Zeynab, Sani Mojtaba, Aghighi Zahra, Moghaddam Meysam Hassani, Eskandari Neda, Mohammadbagheri Esmaeil, Fathi Mobina, Shenasandeh Zahra, Fotouhi Farid, Abdollahifar Mohammad-Amin, Salehi Mina, Bayat Amir-Hossein, Meftahi Gholam Hossein, Aliaghaei Abbas, Rasoolijazi Homa
Аннотация
3-acetylpyridine (3-AP) is a neurotoxin that is known to mainly affect the inferior olivary nucleus (ION) in the brain stem. Although several studies have explored the effect of this neurotoxin, still further investigation is required to understand the impact of this toxin on different parts of the brain. In this research, two groups of rats were studied, the 3-AP-treated and the control groups. Behavioral, stereological, and immunohistochemical analyses were performed. The locomotor activity of the 3-AP-treated rats decreased whereas their anxiety levels were higher than in normal controls. Also, memory performance was impaired in animals in the 3-AP group. Microscopic observations showed a decline in the numerical density of neurons in the hippocampus and striatum along with gliosis. Although this toxin is used to affect the ION, it exerts a neurotoxic effect on different brain regions.