Annals of internal medicine · 2020
Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tartof Sara Y, Qian Lei, Hong Vennis, Wei Rong, Nadjafi Ron F, Fischer Heidi, Li Zhuoxin, Shaw Sally F, Caparosa Susan L, Nau Claudia L, Saxena Tanmai, Rieg Gunter K, Ackerson Bradley K, Sharp Adam L, Skarbinski Jacek, Naik Tej K, Murali Sameer B
Аннотация
BACKGROUND: Obesity, race/ethnicity, and other correlated characteristics have emerged as high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)-associated outcomes, yet studies have not adequately disentangled their effects.
OBJECTIVE: To determine the adjusted effect of body mass index (BMI), associated comorbidities, time, neighborhood-level sociodemographic factors, and other factors on risk for death due to COVID-19.
DESIGN: Retrospective cohort study.
SETTING: Kaiser Permanente Southern California, a large integrated health care organization.
PATIENTS: Kaiser Permanente Southern California members diagnosed with COVID-19 from 13 February to 2 May 2020.
MEASUREMENTS: Multivariable Poisson regression estimated the adjusted effect of BMI and other factors on risk for death at 21 days; models were also stratified by age and sex.
RESULTS: Among 6916 patients with COVID-19, there was a J-shaped association between BMI and risk for death, even after adjustment for obesity-related comorbidities. Compared with patients with a BMI of 18.5 to 24 kg/m2, those with BMIs of 40 to 44 kg/m2 and greater than 45 kg/m2 had relative risks of 2.68 (95% CI, 1.43 to 5.04) and 4.18 (CI, 2.12 to 8.26), respectively. This risk was most striking among those aged 60 years or younger and men. Increased risk for death associated with Black or Latino race/ethnicity or other sociodemographic characteristics was not detected.
LIMITATION: Deaths occurring outside a health care setting and not captured in membership files may have been missed.
CONCLUSION: Obesity plays a profound role in risk for death from COVID-19, particularly in male patients and younger populations. Our capitated system with more equalized health care access may explain the absence of effect of racial/ethnic and socioeconomic disparities on death. Our data highlight the leading role of severe obesity over correlated risk factors, providing a target for early intervention.
PRIMARY FUNDING SOURCE: Roche-Genentech.
OBJECTIVE: To determine the adjusted effect of body mass index (BMI), associated comorbidities, time, neighborhood-level sociodemographic factors, and other factors on risk for death due to COVID-19.
DESIGN: Retrospective cohort study.
SETTING: Kaiser Permanente Southern California, a large integrated health care organization.
PATIENTS: Kaiser Permanente Southern California members diagnosed with COVID-19 from 13 February to 2 May 2020.
MEASUREMENTS: Multivariable Poisson regression estimated the adjusted effect of BMI and other factors on risk for death at 21 days; models were also stratified by age and sex.
RESULTS: Among 6916 patients with COVID-19, there was a J-shaped association between BMI and risk for death, even after adjustment for obesity-related comorbidities. Compared with patients with a BMI of 18.5 to 24 kg/m2, those with BMIs of 40 to 44 kg/m2 and greater than 45 kg/m2 had relative risks of 2.68 (95% CI, 1.43 to 5.04) and 4.18 (CI, 2.12 to 8.26), respectively. This risk was most striking among those aged 60 years or younger and men. Increased risk for death associated with Black or Latino race/ethnicity or other sociodemographic characteristics was not detected.
LIMITATION: Deaths occurring outside a health care setting and not captured in membership files may have been missed.
CONCLUSION: Obesity plays a profound role in risk for death from COVID-19, particularly in male patients and younger populations. Our capitated system with more equalized health care access may explain the absence of effect of racial/ethnic and socioeconomic disparities on death. Our data highlight the leading role of severe obesity over correlated risk factors, providing a target for early intervention.
PRIMARY FUNDING SOURCE: Roche-Genentech.
Предметные рубрики MeSH
AdultAge FactorsAgedAged, 80 and overAsthmaBetacoronavirusBody Mass IndexCOVID-19CaliforniaCohort StudiesComorbidityCoronavirus InfectionsDelivery of Health Care, IntegratedDiabetes MellitusFemaleHumansHyperlipidemiasHypertensionMaleMiddle AgedObesityPandemicsPneumonia, ViralRetrospective StudiesRisk FactorsSARS-CoV-2Sex FactorsYoung Adult