Abdominal radiology (New York) · 2025
68Ga-DOTA-FAPI-04 and 18F-FDG PET/CT: a head-to-head comparison for peritoneal carcinomatosis diagnostic accuracy.
СтатьяСравнительное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Chen Xiaolin, Pang Xiao, Zhao Yan, Liu Yunuan, Jing Fenglian, Yuan Huiqing, Chen Xiaoshan, Li Tianyue, Wang Yingchen, Liu Yali, Han Jingya, Zhang Jingmian, Wang Jianfang, Zhang Zhaoqi, Zhao Xinming
Аннотация
PURPOSE: The study aimed to compare the diagnostic accuracy of 68Ga-DOTA-FAPI-04 (68Ga-FAPI) and 18F-FDG PET/CT for peritoneal carcinomatosis (PC) in patients with various types of cancer.
METHODS: The study enrolled 113 patients with suspected peritoneal malignancy, each of whom underwent 68Ga-FAPI and 18F-FDG PET/CT scans. Lesions in all patients were confirmed through pathology or radiological follow-up. The evaluation and comparison of diagnostic performance, visual scores, maximum standardized uptake value (SUVmax), mean tumor-to-background ratio (TBR), and the peritoneal cancer index (PCI) score were conducted.
RESULTS: Compared to 18F-FDG, 68Ga-FAPI PET/CT presented higher sensitivity, negative predictive value, and accuracy for detecting PC on a patient-level (100% vs. 93.2%, 100% vs. 22.22% and 93.81% vs. 86.73%, respectively). Semi-quantitative evaluation revealed that 68Ga-FAPI PET/CT had significantly higher SUVmax and TBR for PC [(6.06 ± 3.04 vs. 4.82 ± 2.75, P = 0.001) and (8.50 ± 5.01 vs. 2.92 ± 1.67, P < 0.001)]. The PCI-FAPI score for PC was higher than the PCI-FDG score (11.28 ± 7.10 vs. 5.69 ± 5.15, P < 0.001).
CONCLUSIONS: 68Ga-FAPI has demonstrated superior diagnostic accuracy compared to 18F-FDG PET/CT in detecting PC with various types of cancer, particularly gastric cancer. Additionally, 68Ga-FAPI has shown significantly higher uptake and PCI score in PC compared to 18F-FDG, indicating its potential importance in clinical.
METHODS: The study enrolled 113 patients with suspected peritoneal malignancy, each of whom underwent 68Ga-FAPI and 18F-FDG PET/CT scans. Lesions in all patients were confirmed through pathology or radiological follow-up. The evaluation and comparison of diagnostic performance, visual scores, maximum standardized uptake value (SUVmax), mean tumor-to-background ratio (TBR), and the peritoneal cancer index (PCI) score were conducted.
RESULTS: Compared to 18F-FDG, 68Ga-FAPI PET/CT presented higher sensitivity, negative predictive value, and accuracy for detecting PC on a patient-level (100% vs. 93.2%, 100% vs. 22.22% and 93.81% vs. 86.73%, respectively). Semi-quantitative evaluation revealed that 68Ga-FAPI PET/CT had significantly higher SUVmax and TBR for PC [(6.06 ± 3.04 vs. 4.82 ± 2.75, P = 0.001) and (8.50 ± 5.01 vs. 2.92 ± 1.67, P < 0.001)]. The PCI-FAPI score for PC was higher than the PCI-FDG score (11.28 ± 7.10 vs. 5.69 ± 5.15, P < 0.001).
CONCLUSIONS: 68Ga-FAPI has demonstrated superior diagnostic accuracy compared to 18F-FDG PET/CT in detecting PC with various types of cancer, particularly gastric cancer. Additionally, 68Ga-FAPI has shown significantly higher uptake and PCI score in PC compared to 18F-FDG, indicating its potential importance in clinical.