The British journal of psychiatry : the journal of mental science · 2009
Structure of genetic and environmental risk factors for dimensional representations of DSM-IV anxiety disorders.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАTwin StudyНазвание и аннотация: Перевод пока не подготовлен
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Tambs Kristian, Czajkowsky Nikolai, Røysamb Espen, Neale Michael C, Reichborn-Kjennerud Ted, Aggen Steven H, Harris Jennifer R, Ørstavik Ragnhild E, Kendler Kenneth S
Аннотация
BACKGROUND: Twin data permit decomposition of comorbidity into genetically and environmentally derived correlations. No previous twin study includes all major forms of anxiety disorder.
AIMS: To estimate the degree to which genetic and environmental risk factors are shared rather than unique to dimensionally scored panic disorder, generalised anxiety disorder, phobias, obsessive-compulsive disorder and post-traumatic stress disorder.
METHOD: Data obtained from 2801 young-adult Norwegian twins by means of the Composite International Diagnostic Interview were analysed with the Mx program.
RESULTS: A multivariate common factor model fitted best. The latent liability to all anxiety disorders was substantially more heritable (54%) than the individual disorders (23% to 40%). Most of the genetic effect was common to the disorders. Genes contributed just over 50% to the covariance between liabilities.
CONCLUSIONS: The five anxiety disorders all share genetic and environmental risk factors. This has implications for the revision of the anxiety disorder section in DSM-V.
AIMS: To estimate the degree to which genetic and environmental risk factors are shared rather than unique to dimensionally scored panic disorder, generalised anxiety disorder, phobias, obsessive-compulsive disorder and post-traumatic stress disorder.
METHOD: Data obtained from 2801 young-adult Norwegian twins by means of the Composite International Diagnostic Interview were analysed with the Mx program.
RESULTS: A multivariate common factor model fitted best. The latent liability to all anxiety disorders was substantially more heritable (54%) than the individual disorders (23% to 40%). Most of the genetic effect was common to the disorders. Genes contributed just over 50% to the covariance between liabilities.
CONCLUSIONS: The five anxiety disorders all share genetic and environmental risk factors. This has implications for the revision of the anxiety disorder section in DSM-V.
Предметные рубрики MeSH
AdultAnxiety DisordersComorbidityData Interpretation, StatisticalDiagnostic and Statistical Manual of Mental DisordersDiseases in TwinsFemaleGenetic Predisposition to DiseaseHumansMaleNorwayPhenotypeRisk FactorsSocial EnvironmentStatistics as TopicSurveys and QuestionnairesTwin Studies as TopicTwins, DizygoticTwins, MonozygoticYoung Adult