Clinical oral investigations · 2010
Mannose-binding lectin gene (MBL-2) polymorphism in oral lichen planus.
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Barkokebas Andreza, de Albuquerque T Carvalho Alessandra, de Souza Paulo Roberto Eleutério, Gomez Ricardo Santiago, Xavier Guilherme Machado, Ribeiro Camila Maria Beder, Crovella Sergio, Porter Stephen Ross, Leão Jair Carneiro
Аннотация
TNF-α may be associated with the etiopathogenesis of oral lichen planus (OLP), and it has been suggested that polymorphism of mannose-binding lectin (MBL) increases the in vitro production of TNF- α. The aim of the present study was to assess the relevance of genetic diversity of MBL in OLP. The study sample comprised 90 individuals, 45 OLP patients and 45 healthy volunteers. MBL-2 gene was amplified using real-time PCR. Frequency of A/A genotype was 55.6% in OLP and 53.3% in healthy volunteers. Likewise, A/0 heterozygote genotype was found in 42.2% and 35.6%; 2.2% and 11.1%, had the recessive 0/0 genotype respectively. Frequencies of the "A" and "0" alleles were 77% and 23% in the OLP group and 71.2% in control group. There were no statistically significant differences regarding genotype frequency (p = 0.546) or allele frequency (p = 0.497). In conclusion, no significant association was found between polymorphism of MBL-2 gene and OLP.